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Thromb Haemost 96:488491 Eldor A, Durst R, Hy-Am E, Goldfarb A, Gillis S, Rachmilewitz EA, Abramov A, Maclouf J, Godefray YC, de Raucourt E, Guillin MC (1999) A chronic hypercoagulable state in patients with beta-thalassaemia major is already present in childhood

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suggesting that, at high concentrations, IGF-1 has effects not simply mediated by suppressing the effect of GH on hepatic insulin sensitivity [129, 209]

Later the same group showed that PLC plays crucial role in skin inflammation induced by phorbol ester, linking the initial inflammation to the subsequent skin cancer development [23]