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Virol J (2009) 6:5.10.1186/1743-422x-6-5 59 BlackardJTKongLHuberAKTomerY

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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

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Hydroxyurea (0.5g bid 810 days in the course of the disease) and idarubicin (8mgm -2 d -1 Days 911 of the course of disease) were used to reduce leukocytosis, and liver protection measures were implemented