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Research suggests cycles of up to 12 weeks with breaks in between to maintain efficacy and prevent tolerance

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347 Activated TGF- binds to its transmembrane receptor (TR), subsequently inducing the phosphorylation of suppressor of mothers against decapentaplegic (SMAD) and its translocation into the nucleus, which suppresses hepatocyte proliferation by inhibiting the expression of downstream DNA synthesis-related genes

The search strategy was based on a combination of keywords and subject headings, including: breast cancer, breast cancer and oxidative stress, breast cancer prevalence, reactive oxygen species in breast cancer, cancer statistics, medicinal plants in breast cancer treatment, dietary antioxidants and breast cancer, and antioxidants in breast cancer treatment. After the initial search, duplicate records were removed and the remaining studies were subjected to a two-stage screening process

doi: 10.1016/j.ijcard.2012.05.038

3,210 Multiple randomized controlled trials and meta-analyses have shown letrozole has a similar safety profile and is more effective than clomiphene citrate in women with PCOS