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The phase 2 trial data shows that fatigue rates varied more by titration speed than by final dose

The men who keep it off dont have more willpower

At follow-up, both groups attained comparable median weight change and reduction in mean body weight

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Reid TJ et al

They bind with the enzyme CYP3A4 3 , which means that drugs such as tamoxifen cannot use the engaged CYP3A4 enzymes to convert into their active forms in the body, reducing the drugs effectiveness