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Users who stop early or use the tablets inconsistently are the most common source of "it doesn't work" feedback, when the actual issue is timeline mismatch with biology

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Skalny AA, Tinkov AA, Medvedeva YS, Alchinova IB, Karganov MY, Skalny AV et al (2015) Effect of short-term zinc supplementation on zinc and selenium tissue distribution and serum antioxidant enzymes

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Some researchers have proposed that concentrations above approximately 6 to 7 mol/L may already indicate suboptimal methylation and increased long term health risk