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Instead, the drug failed to show non-inferiority against Lillys Zepbound in the REDEFINE 4 Phase 3 head-to-head trial reported in February 2026, delivering 23.0% weight loss versus 25.5% for tirzepatide, triggering another wave of investor disappointment

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By integrating BBRs multi-target pharmacology with cutting-edge delivery technologies, this review provides a transformative perspective, positioning BBR not merely as a natural product but as a scaffold for the rational development of next-generation, multi-target diabetes therapeutics

243 McKeigue, P