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To be accepted as a surrogate endpoint, a biomarker must demonstrate that changes in its levels reliably and reproducibly predict clinical benefit across multiple interventions and study populations, an evidentiary standard that few neurodegeneration-related markers currently meet [583]

Response of gastric inhibitory polypeptide (GIP) to test meal in chronic pancreatitisrelationship to endocrine and exocrine insufficiency

10.1016/j.cmet.2015.12.006 154 PeetersT

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Most trials have focused on durations from 18 to 36 weeks, and data on extended use are scarce