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Although natural compounds such as resveratrol, quercetin, and curcumin target multiple pathways and show efficacy in preclinical MASLD models, their broad activity spectrum may result in off-target interactions

For patients with CKD, SGLT2 inhibitors provide significant protection against cardiovascular and renal outcomes

Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinsons disease

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For example, the water channel AQP-4 is downregulated early in cerebrovascular degeneration, which may allow detection of early hypoperfusion (Lan et al., 2016