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The matched cohorts comprised 25,060 patients each, achieving excellent equilibrium across most variables

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GSSG forms when two GSH molecules are linked by a disulfide bond between their cysteine residues

Journal of translational medicine , 22 (1), 954

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Clinical Highlights of Retatrutide Study: 48-week, double-blind, placebo-controlled Phase 2 trial Results: ~22.8% weight loss (8 mg dose), ~28.2% weight loss (12 mg dose) ~0.9% HbA1c reduction Significant improvements in cardiometabolic risk factors Safety & Tolerability Most common side effects: nausea, vomiting, diarrhea, abdominal discomfort, constipation typically mild to moderate and dose-dependent