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Tirzepatide at the highest doses (15 mg) may be associated with slightly more GI side effects, which makes sense given its additional GIP receptor activity

It has the highest prevalence in New England

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GLP-1-producing neurons in the NTS project axon terminals widely, densely innervating regions involved in autonomic and metabolic control, such as hypothalamic and thalamic nuclei and the NTS itself (Larsen et al., 1997