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3.2.2 BA and secondary BAs As pivotal messengers bridging the gut microbiota and the host cardiovascular system, the BA familyincluding primary and secondary BAsforms a multifaceted regulatory network through activation of nuclear receptors such as TGR5, FXR, and PXR

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This disrupts normal calcium cycling in cardiomyocytes, particularly during diastole, resulting in impaired Ca 2+ transport and excitation-contraction coupling, as evidenced by reduced contraction amplitude, left ventricular developing pressure, and an impaired force-frequency relationship (Joulin et al., 2009)

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Long chain acetylcarnitine esters transport fatty acyl moieties into the mitochondria (Figure 2)