Menadione treatment depleted cellular GSH and reduced the GSH/glutathione disulfide ratio, but glutathione amino acid precursor supplementation effectively restored GSH levels and improved the redox balance
Interestingly, we also found gpoA , which encodes for a glutathione peroxidase that have not been reported in S
As the primary redox buffer, it regulates the ratio between its oxidized form (GSSG) and reduced form (GSH), which determines the entire cellular redox environment
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The Blue loop is the actual position of the residue in the detected structure