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Unlike alpha-MSH, KPV does not activate melanocortin receptors, so it does not cause skin pigmentation changes or appetite effects

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These findings indicate that TTP, in particular, may serve as a potential antihypertensive candidate with potent ACE-inhibitory activity [177]

Safety Considerations and Who Should Start Conservatively Female patients with liver disease, severe kidney impairment, or uncontrolled thyroid dysfunction require careful dosing oversight and may need lower starting doses or extended monitoring intervals

However, many studies did not observe performance benefits

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