It might be better to start at a mid-level dose. Muscle loss is a bigger concern than temporary digestive side effects Oh Sang-woo, a professor of family medicine at Dongguk University Ilsan Hospital, said both Mounjaro and Wegovy can cause gastrointestinal side effects such as nausea, bloating, constipation and diarrhea as the dose increases
Paradkar PN, Zumbrennen KB, Paw BH, Ward DM, Kaplan J
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doi: 10.1096/fj.202000564R 86 HendersonJDuffyLStrattonRFordDO'ReillyS
Some people who do not require a maximum dose are also trying to save money by filling prescriptions for high-capacity pens and counting clicks to administer smaller doses
However, retatrutide remains investigational and is not yet approved in the UK or United States, with regulatory submission still pending and approval not anticipated before 2027 at the earliest