Based on Phase 2 trial protocols by Eli Lilly, initiation was typically at 2 mg once weekly via subcutaneous injection, with gradual dose escalation thereafter
Diarrhea Description : Loose, watery stools
That said, its worth comparing costs, including any savings offers or pharmacy discounts especially if this is a medication youre considering long term
In December 2025, Eli Lilly published the first positive Phase 3 readout for retatrutide (LY3437943), the triple-agonist peptide that had, until then, only been validated at Phase 2 scale
A positive CVOT readout is what unlocks a broad cardiovascular-risk-reduction claim on the eventual label, analogous to what LEADER did for liraglutide and SELECT did for semaglutide
It is ideal for researchers starting at low doses or those who want to minimize waste during short protocols