Food and Drug Administration (FDA) in 2021 for chronic weight management in adults and children 12 and older with obesity (BMI of 30 or more) and for adults who are overweight (BMI of 27 or more) with one or more weight-related health conditions, such as type 2 diabetes or high blood pressure
Additionally, the concurrent administration of corticosteroids (or ACTH) and testosterone can increase the likelihood of fluid retention and edema, which is particularly concerning in patients with heart failure or advanced liver disease
But then just recently, they revisited that data and they did some follow-up
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Biochimica Biophysica Acta (BBA) - Bioenergetics 1817 (10), 18331838
J Lipids (2011) 2011:575840