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In the LEADER trial evaluating liraglutide, patients experienced a mean heart rate increase of approximately 3 beats per minute compared to placebo over the study duration

Its one of the main reasons people are exploring the oral semaglutide experience

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These usually occur during the dose-escalation phase and tend to diminish over time. Patients can improve tolerability by consuming smaller portions and avoiding high-fat or spicy meals. Dosing should start low and be increased gradually based on tolerance and clinical goals. Administration and Storage Considerations Injectable agents such as dulaglutide and semaglutide must be refrigerated before the first use