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Rather than acting broadly across the microbiome, it lives within the mucus layer itself, and early research suggests this is how it helps reinforce the gut barrier and support the body's everyday response to stressors

Yehuda, S., Kastin, A

Under acidic TME conditions, FOXP3 + cells act as potent immunosuppressants, and prolonged lactate accumulation induces upregulation of H3K18 lactylation in NKT cells, leading to FOXP3 + NKT cell production (108)

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Disease can lower glutathione through inflammation, oxidative reactions, impaired synthesis, altered nutrient status, tissue damage or medication effects