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Note: Semaglutide should be combined with lifestyle changes like a lower-calorie diet
Switching from semaglutide to tirzepatide often restarts the weight loss trajectory, presumably by engaging additional receptor pathways that monotherapy does not activate
That progression from plateau to reversal signals something beyond normal adaptation
Also, its highly advisable to avoid doubling up on doses, as this can increase the risk of side effects like nausea, vomiting, or low blood sugar
References: Effects of Semaglutide on Chronic Kidney Disease in Type 2 Diabetes, Perkovic V