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Association between fecal microbiota and generalized anxiety disorder: severity and early treatment response

This is specifically manifested by increased mitochondrial DNA content, upregulation of related gene expression, improvement of the oxidative metabolism, and elevation of the expression levels of key proteins involved in oxidative phosphorylation [26]

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NAD + depletion, as seen in aging and certain diseases, is linked to mitochondrial dysfunction, impaired oxidative metabolism, and decreased repair capacity 3,4