reported that KGN cells treated with DHEA exhibited ferroptosis characterized by decreased viability, inhibited GPX4 and SLC7A11 expression, increased ACSL4 expression, increased MDA levels and ROS accumulation, and increased lipid peroxidation
There is no obvious similarity in chemical structure among all of these substances, but they have in common the ability to stimulate the pentose phosphate pathway in red blood cells, which must mean that they are able to oxidize NADPH directly or indirectly
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In line with these findings, Yuan et al
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