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Full text: Sinha R, Sinha I, Calcagnotto A, et al

The three major routes of administration used for skin lightening are topical (creams, face washes), oral (capsules and sublingual/buccal tablets) and intravenous injections

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It was first described and also named in 1921 (Hopkins) and in 1935 it could be synthesized and its structure was definitively established

Notably, in mice studies, GH secretagogue receptor suppression in adipose tissues protects against obesity and insulin resistance (97), whereas IGF-I increases skeletal muscle insulin sensitivity (98)