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Older adults with genetic predispositions toward insulin resistance may benefit from tirzepatide's dual-receptor action, while younger patients with specific GLP1R profiles might respond exceptionally well to semaglutide alone

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This action is similar to natural GHRH, but with less effect on other hormones such as cortisol and prolactin

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This is substantiated by two large, randomized placebo-controlled trials, the Womens Health Initiative study 11 and the Heart and Estrogen/Progestin Replacement study 12 that found a significant reduction in the incidence of diabetes in women assigned to menopausal estrogen therapy, thus providing evidence for the antidiabetic action of estrogen in women