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Graphical Abstract Similar content being viewed by others Introduction Ulcerative colitis (UC), characterized by chronic intestinal inflammation and epithelial barrier dysfunction, remains a therapeutic challenge due to its complex etiology involving dysregulated immune responses, microbiota dysbiosis, and aberrant cell death pathways [1, 2]

Selank: pain perception modulation Selank approaches back pain from a different angle, modulating the neurological perception of pain rather than directly healing tissue