A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction
Supply the basics your cells burn through every day: fullspectrum minerals from quality sea salt in your water, essential amino acids to cover protein synthesis without gut burden, vitamin D3 with K2, a methylated B complex, and magnesium at night
Must be used as a single-dose preparation
Thompson, R
Rausch T, Gromes R, Liedschulte V, Muller I, Bogs J, Galovic V, Wachter A (2007) Novel insight into the regulation of GSH biosynthesis in higher plants
Briefly, AML12 cells were pretreated according to the experimental purpose