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Broadhouse et al demonstrated a clear protection of the left hippocampus with 6 months of high-intensity RT (3 sets of 8 repetitions at 80% 1RM, two or three times per week) compared to shaman effect that persisted 1-year post-intervention in the 200 older adults studied (Hainmueller and Bartos, 2020), and hippocampal synaptic relay ( The benefits of RT on hippocampal subfields are further supported by recent work from Vints et al, demonstrating that even 12 weeks of progressive RT peaking at 85% of 1RM was sufficient in improving CA1, CA4, subiculum, and dentate gyrus volume in 70 older men and women (Vints et al., 2024)
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