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TB-500 (synthetic TB4) has been clinically tested for its wound healing potential, with the following two studies worth noting: In a randomized, double-blind, placebo-controlled study with dose escalation, patients suffering from venous stasis ulcers were administered synthetic TB4 locally over a period of 84 days

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Mice were maintained on a chow diet (Teklad Global 18% Protein Rodent Diet 2918, Madison, WI) from weaning at three weeks of age until six weeks of age