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Free radicals and oxidative stress are known to degrade collagen fibers through a process called collagenolysis

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In particular, a systematic review of 5632 patients concluded that augmentation therapy has a slight effect in reducing the decline in lung function, showing a 23% slowdown in the decline of forced expiratory volume in one second (FEV1) (13.4 mL/year, 95% CI 1.5-25.3 mL/year) in treated patients compared to the placebo group (83)

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