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Another evidence linking the NAD + metabolism with DNA methylation is the NNMT, which transfers the methyl group from SAM to NAM, producing S-adenosylhomocysteine (SAH) and a stable metabolites 1-methylnicotinamide (MNA)

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[2] S J Brandt, T D Mller, R D DiMarchi, M H Tschp, K Stemmer Peptide-based multi-agonists: a new paradigm in metabolic pharmacology J Intern Med