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Nevertheless, in the past few years, seven randomized phase III clinical trials, which tested other first-line and second-line treatments, in intermediate-stage or advanced-stage HCC patients have not found any obvious OS benefits (Llovet et al., 2015)

Several peptides with strong physiological phenotypes were identified before their receptors were cloned or fully characterized, limiting structureactivity relationship studies and medicinal chemistry optimization

Dermatol Pract Concept (2019) 10:e2020001

Of note, the exaggerated levels of pro-inflammatory mediators and the suppressed AKT level are considered the key contributors in disrupting BDNF signaling, which lead to consequent enhancement in neuronal apoptosis and impairment in memory functions (Rossi et al

doi: 10.1136/gut.52.3.439

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