But as doses escalate toward the higher end of protocols, the cumulative effect of fill weight variance becomes more relevant
The dehydration risk from severe vomiting and diarrhea, which can lead to acute kidney injury, may partially explain this difference, as semaglutide causes more severe GI events at weight loss doses
The confusion usually arises because both treatments begin with very small weekly starting doses
Research on restarting semaglutide after a break provides guidance on re-initiation protocols, though specific allodynia-focused re-escalation data is limited
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Rectal bleeding beyond minor streaking from hemorrhoids, particularly if dark or tarry stools are present, necessitates investigation to exclude gastrointestinal pathology