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It is extremely rare for such a tumor to occur in childhood, but, when it does, the excessive GH can cause excessive growth, traditionally referred to as pituitary gigantism

The main intracellular antioxidant enzymes participating in the protection of cells against the damaging effects of ROS are glutathione peroxidase (GPx) and superoxide dismutase (SOD) (6, 7)

[1] Inactivation of 2-OHE 2 is catalysed by catechol-O-methyltransferase (COMT), [2] with COMT exhibiting a faster rate for the methylation of 2-OHE 2 versus 4-OH-E 2

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Haverty T, Wyatt DJ, Porter KM, Leubitz A, Banks K, Goodyer P, Hu MY (2021) Phase 1 renal impairment trial results supports targeted individualized dosing of ELX-02 in patients with nephropathic cystinosis

The firstand most importantis that they actually seem to work