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CagriSema vs Comparators Feature Receptor targets CagriSema Amylin/calcitonin + GLP-1 Tirzepatide (Zepbound) GIP + GLP-1 Semaglutide alone (Wegovy) GLP-1 Cagrilintide alone Amylin/calcitonin (DACRA) Feature Dosing frequency CagriSema Once weekly Tirzepatide (Zepbound) Once weekly Semaglutide alone (Wegovy) Once weekly Cagrilintide alone Once weekly Feature Maintenance dose CagriSema 2.4 mg + 2.4 mg Tirzepatide (Zepbound) Up to 15 mg Semaglutide alone (Wegovy) 2.4 mg Cagrilintide alone 2.4 mg (in REDEFINE arms) Feature Headline weight loss CagriSema 20.4% at 68 wks (REDEFINE 1, treatment-policy) Tirzepatide (Zepbound) Up to 22.5% at 72 wks (SURMOUNT-1, 15 mg arm) Semaglutide alone (Wegovy) 14.9% at 68 wks (REDEFINE 1 reference arm) Cagrilintide alone 11.5% at 68 wks (REDEFINE 1 reference arm) Feature FDA status (June 2026) CagriSema NDA filed Dec 2025

As such, more than 90% of circulating ApoB resides in LDL particles 38

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Sensitivity to platinum-based chemotherapy drugs was then compared in A2780 and A2780/GSTP1 cells and significant differences in chemosensitivity observed following treatment with cisplatin (2.28-fold decrease in IC 50, P =0.03, Figure 2B) and carboplatin (4.83-fold decrease in IC 50, P =0.007, Figure 2C), and a less pronounced decrease in sensitivity to paclitaxel (1.58-fold increase in IC 50, P =0.02, Figure 2D)

In 39 patients (19 in the loading dose group and 20 in the no loading dose group), MMSE scores were similar at baseline (27 vs