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( c ) Cells were incubated with 13 C 6 -glucose, and M + 2 acetyl-CoA was measured (FT282-EV and Ovcar8-EV: n = 8/group, FT282-CCNE1 and Ovcar8-CCNE1: n = 7/group

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Its deficiency decreases -KG, impairing JMJD3/UTX demethylase activity, increasing H3K27me3, and promoting the expression of apoptosis inhibitors such as XIAP and survivin [104]