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10.1038/s41586-019-1705-2 5 BhatM

10.1111/j.1365-2826.2007.01563.x J

As mitochondria are a major target of APAP hepatotoxicity, mitochondrial quality control and clearance of dysfunctional mitochondria through mitophagy, emerges as an important strategy to limit oxidative stress and the engagement of molecular events leading to cell death

But it also raises IGF-1, disrupts glucose metabolism, and can accelerate unwanted tissue growth

He was studying liver disease and noticed that plasma from younger people caused older liver tissue to behave like younger tissue

Figure 15: Gouty Destruction at Multiple Finger Joints