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Methods Enzymol 348:93112 Holmgren A, Sengupta R (2010) The use of thiols by ribonucleotide reductase

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In the adjuvant setting, the KATHERINE study offers non-pCR patients after neoadjuvant therapy an opportunity to switch to alternative anti-HER2 drugs, marking a satisfactory exploration

DA oxidation generates deleterious and highly reactive DAQs, which can covalently conjugate with sulfhydryl and hydroxyl groups of protein cysteine and tyrosine residues, respectively, to form MA adductive products