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Costunolide, a sesquiterpene lactone, demonstrated gut-brain regulatory effects in a chronic stress-induced IBS model by increasing levels of serotonin (5-HT), brain-derived neurotrophic factor, GluN2A, p-ERK1/2, and p-CREB in the hippocampus

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It does not cause photosensitivity (unlike retinoids), does not thin the skin (unlike corticosteroids), and does not require a tolerance-building period