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Filtering the proteomic dataset using the same list of ferroptosis-related markers as above, 18 proteins were differentially expressed in AD compared to isogenic brain organoids (Fig

There were some problems with interpreting the study, since almost all the patients who died had already stopped their gout medication, whether allopurinol or febuxostat

Allocati N, Masulli M, Di Ilio C, Federici L (2018) Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

Compound 102 exhibited GPX4 activating effects in a concentration-dependent manner ( Figure 3 and Supplementary Figure S3 ), with both increased ratio of 5-HETE and LTB 4 and increased concentrations of 12-HETE and 15-HETE

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The loss of pigment in hair shafts because of decreased melanocyte function is typically known as graying, or going gray, although the exact cellular and molecular mechanisms are not yet completely understood