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Although basal XOR expression is typically low in humans, various factors such as hypoxia, ischemia-reperfusion injury, interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-), and corticosteroid treatment can markedly enhance XOR transcription

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Many patients report better sleep, more energy, and improved skin within 24 weeks

In addition to mitochondria, peroxisomes also participate in ROS production

Smith SM, Vale WW (2006) The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress

Siegel 2013