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10.1146/annurev.pharmtox.48.113006.094746 Annu

Mice carrying null mutations of the genes encoding insulin-like growth factor I ( Igf-1 ) and type 1 IGF receptor ( Igf1r )

(PubMed) Ashor AW, Siervo M, Lara J, Oggioni C, Afshar S, Mathers JC

The Pharmacodynamic Mechanisms That Do Apply ALA activates AMP-activated protein kinase (AMPK) in skeletal muscle and adipose tissue, increasing glucose transporter GLUT4 translocation and improving insulin-mediated glucose disposal

ROS can oxidize MAPK and hyper-activate MAPK/ERK pro-proliferative signaling (Son et al