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Patients with or without GD and GO who had low serum Se levels showed relatively high serum Cu levels in GD patients, while patients with GD and GO conversely had low serum Cu levels (72)

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Semaglutides introduction of a fatty acid side chain at position 26 Lys allows reversible binding to plasma albumin and reduces renal clearance, and substitution of amino acids at positions 8 and 34 with Aib and Arg avoids its degradation by DPP-4 and prevents fatty acid binding at the wrong site, resulting in a once-weekly dosing (Lau et al., 2015

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