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Synergistic Efficacy of CPI 613 Combined with Enz in PCa Treatment CPI 613, a novel PDHA1 inhibitor, has demonstrated antitumor activity by disrupting mitochondrial metabolism through phosphorylation and inactivation of PDHA1, which plays a key role in PCa cell survival, and exhibits low toxicity to normal prostate epithelial cells (RWPE1) while effectively killing PCa cells (Supplementary Fig