Notably, this heat stroke-induced LIRI differs fundamentally from reperfusion injury in hypovolemic shock or surgical contexts: in heat stroke, reperfusion is preceded by hyperthermia-induced endothelial damage and systemic inflammatory priming, which amplify oxidative stress (e.g., xanthine oxidase activation) and neutrophil infiltration
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The glycolysis metabolite lactate upregulates SRSF10 expression via H3K18la and eventually forms a circMETTL3/METTL3-156aa/LDHA/lactate/SRSF10 positive feedback loop in THP-1 cells
2018;18(1):e1424
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While most previous treatments worked by reducing platelet destruction through a general immune system effect, newer medicines target the pathophysiology of ITP more precisely by increasing platelet production or decreasing platelet destruction
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