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However, the exact mechanism of MHA associated with mTOR inhibitors is currently unknown

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Prednisone, like other corticosteroids should not be administered concomitantly with: - Barbiturates, carbamazepine, phenytoin, rifampin or ephedrine: these drugs enhance the metabolism of corticosteroids reducing their therapeutic action

Ahamad R, Parveen S

This phenomenon can induce a refractory response in melasma patients that can enhance the possibility of recurrence (Sanchez et al., 1981)

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