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Mounjaro may provide slightly greater weight loss at the highest dose, but cost and long-term approvals are still evolving

Amanda Velazquez, director of obesity medicine in the Department of Surgery at Cedars-Sinai Medical Center in Los Angeles

The therapeutic benefit of interventions also needs to be controlled for in research

The treatment starts with a low dose to minimize side effects of slow gastric emptying, like heartburn, burping, and feeling bloated

This supports balanced hormone levels and reduces the risk of side effects often associated with synthetic hormone therapies

Its relevance to women's hormonal health is indirect: gut mucosal integrity and chronic low-grade inflammation are now recognised as meaningful modulators of hormonal function particularly in PCOS, Hashimoto's thyroiditis, and perimenopause-associated metabolic disruption