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Most studies show noticeable effects after 8 to 12 weeks of daily use combined with strength training

1 Theres no dedicated cardiovascular outcomes trial for retatrutide yet

Caffeine is a mild diuretic, so compensate with extra water intake

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*Correspondence: Predrag Sikiric, [email protected] This article was submitted to Gastrointestinal and Hepatic Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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