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Heterozygous knockout of individual genes within the locus also results in some overlapping, pleiotropic phenotypes: for example, Tbx1 hemizygosity causes deficits in working memory, social interaction and communication, as well as repetitive behavior tendencies, phenotypic traits commonly observed in human ASD [153]

Long-term mild excess of thyroid hormone causes impaired cardiac reserve and exercise capacity (353)

Metabolism 51(11):1389-91, 2002

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Crevasse is characterized by a cluster of hydrophobic phenylalanine residues, including Phe279 6.51 , Phe286 6.58 , Phe290 6.62 , Phe309 7.39 , and Phe312 7.42 (Figure 3)

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