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This modest decrease may be due to differences in sympathetic activity between D 2 / and D 2 +/+ mice [11, 27]

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Autopsies of patients with ASD have revealed significant structural changes in their brains, including altered grey/white matter ratios, increased neuronal numbers, decreased neuronal body volume, increased numbers of glia, and changes in dendritic spines and cerebral blood vessels

We have previously demonstrated an increased nicotinamide:nicotinic acid ratio in the adipose tissues of 5A-1MQ-treated DIO mice 13

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11 Supplementation with leucovorin calcium may represent a relatively well tolerated may to manage some symptoms associated with ASD