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The phase I study proved good safety, prolonged pharmacokinetics, and significant weight loss trends (171)

Glipizide, Gliclazide)

doi: 10.1016/j.cmet.2013.04.008 43 DelrueCSpeeckaertMM

GIP is a hormone that also encourages insulin production, which is why it is effective as a diabetes medication

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7 Subcutaneous semaglutide was approved in 2021 and 2022 as Wegovy for weight loss in patients 12 and older after the STEP1 trial showed patients who took subcutaneous semaglutide had a -14.9% body weight reduction (-15.3kg) compared to -2.4% (-2.6kg) with placebo after 68 weeks