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Blocking mitophagy reduces mitochondrial function, aggravates mtDNA-mediated inflammation, and increases cell apoptosis in M9a+sh EPAS1 cells during hypoxia To further elucidate the role of mitophagy in the adaptation of Tibetans to hypoxia, we used Mdivi-1, a selective DRP1 inhibitor, to suppress mitophagy (Fig

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